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Why Collection Timing Decides Whether Colostrum Works

References for "Why Collection Timing Decides Whether Colostrum Works," Metabolic Health Initiative newsletter, August 2026. Numbers match the bracketed citations in the article. Each link opens the PubMed record.

  1. Playford RJ, Weiser MJ. Bovine Colostrum: Its Constituents and Uses. Nutrients. 2021;13(1):265. PubMed. Disclosure: funded by PanTheryx Inc.; both authors are PanTheryx employees.
  2. Fischer-Tlustos AJ, Hertogs K, van Niekerk JK, et al. Oligosaccharide concentrations in colostrum, transition milk, and mature milk of primi- and multiparous Holstein cows during the first week of lactation. J Dairy Sci. 2020;103(4):3683-3695. PubMed
  3. Playford RJ, Cattell M, Marchbank T. Marked variability in bioactivity between commercially available bovine colostrum for human use; implications for clinical trials. PLoS One. 2020;15(6):e0234719. PubMed
  4. Hałasa M, Maciejewska-Markiewicz D, Baśkiewicz-Hałasa M, et al. Post-Delivery Milking Delay Influence on the Effect of Oral Supplementation with Bovine Colostrum as Measured with Intestinal Permeability Test. Medicina (Kaunas). 2020;56(10):495. PubMed
  5. Eslamian G, Ardehali SH, Baghestani AR, Vahdat Shariatpanahi Z. Effects of early enteral bovine colostrum supplementation on intestinal permeability in critically ill patients: A randomized, double-blind, placebo-controlled study. Nutrition. 2019;60:106-111. PubMed
  6. Hajihashemi P, Haghighatdoost F, Kassaian N, et al. Bovine Colostrum in Increased Intestinal Permeability in Healthy Athletes and Patients: A Meta-Analysis of Randomized Clinical Trials. Dig Dis Sci. 2024;69(4):1345-1360. PubMed
  7. Buckley JD, Butler RN, Southcott E, Brinkworth GD. Bovine colostrum supplementation during running training increases intestinal permeability. Nutrients. 2009;1(2):224-234. PubMed
  8. Roos N, Mahé S, Benamouzig R, et al. 15N-labeled immunoglobulins from bovine colostrum are partially resistant to digestion in human intestine. J Nutr. 1995;125(5):1238-1244. PubMed
  9. Warny M, Fatimi A, Bostwick EF, et al. Bovine immunoglobulin concentrate-clostridium difficile retains C difficile toxin neutralising activity after passage through the human stomach and small intestine. Gut. 1999;44(2):212-217. PubMed
  10. Główka N, Durkalec-Michalski K, Woźniewicz M. Immunological Outcomes of Bovine Colostrum Supplementation in Trained and Physically Active People: A Systematic Review and Meta-Analysis. Nutrients. 2020;12(4):1023. PubMed
  11. Kuipers H, van Breda E, Verlaan G, Smeets R. Effects of oral bovine colostrum supplementation on serum insulin-like growth factor-I levels. Nutrition. 2002;18(7-8):566-567. PubMed